EFSA Rules on Safety, Efficacy of L-arginine From Corynebacterium glutamicum KCTC 10423BP

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on L-Arginine produced by Corynebacterium glutamicum KCTC 10423BP.

L-Arginine is considered as a non-essential amino acid for most adult mammalian species, but it is classified as essential for birds, fish, possibly reptiles and also for strict carnivores.

The use of L-Arginine produced by C. glutamicum KCTC 10423BP is safe for target species when supplemented to diets in appropriate amounts. There are no safety concerns arising from ruminal l-arginine metabolism.

Considering the high purity of the product under assessment, no risk is expected for the consumer from the use of L-Arginine produced by C. glutamicum KCTC 10423BP as a feed additive. The composition of edible tissues and products of animal origin will not be altered by the use of L-Arginine in animal nutrition.

L-Arginine is not irritating to skin or eyes and is not likely to be a skin sensitiser. Although there is a potential for user exposure by inhalation, there is evidence of no acute toxicity by the inhalation route.

The use of L-Arginine produced by C. glutamicum KCTC 10423BP in animal nutrition would not pose a risk to the environment.

L-Arginine produced by C. glutamicum KCTC 10423BP is an effective source of arginine for all species. For the supplemental L-Arginine to be fully efficacious in ruminants, it requires protection against degradation in the rumen.

The FEEDAP Panel made two recommendations related to the description of the additive and the specification for the maximum water content in the product.